Increased Autoimmunity Burden Is a Risk Factor for Developing Irritable Bowel Syndrome-Like Symptoms in Quiescent Inflammatory Bowel Disease
Among patients with IBD with endoscopic remission at baseline, 20.1% developed IBS-like symptoms within one year. The presence of autoimmune comorbidity was significantly associated with earlier development of IBS-like symptoms. These findings suggest that immune system dysregulation may play a role in persistent gastrointestinal symptoms and highlight the need for further research into the pathophysiology of IBS-like symptoms in quiescent IBD.
Authors
- Andrew Chang (ORCID: https://orcid.org/0000-0002-0671-0228)
- Nirupama Bonthala (ORCID: https://orcid.org/0000-0001-7511-2291)
- Divya P. Prajapati (ORCID: https://orcid.org/0000-0002-9693-0469)
- Berkeley N. Limketkai (ORCID: https://orcid.org/0000-0003-2714-6934)
- Janice Oh (ORCID: https://orcid.org/0000-0002-6621-8227)
- Alexandra C. Greb
- Rhett Harmon
- Andrea Shin
- Mark Baniqued
- Bita Shahrvini
- Lin Chang
- Jenny S. Sauk
Institutions
- University of California, Los Angeles (US)
- UCLA Health (US)
- UCLA Medical Center (US)
- Olive View-UCLA Medical Center (US)
Publication Details
- Journal
- Digestive Diseases and Sciences
- Published
- 2026-01-03
- DOI
- https://doi.org/10.1007/s10620-025-09633-4
- Primary Topic
- Gastrointestinal motility and disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00