LDOC1 connects histone H2B monoubiquitination to tumor cell plasticity in non-small cell lung cancer
LDOC1-mediated chromatin remodeling, through regulation of H2Bub1 recruitment and turnover, represents a key mechanism promoting NSCLC progression. The LDOC1-H2Bub1 axis, potentially involving THAP12, shapes chromatin accessibility and metastatic transcriptional programs, providing mechanistic and clinical insights into tumor aggressiveness and therapeutic response.
Authors
- Wei-Hsuan Yu (ORCID: https://orcid.org/0000-0003-3569-7795)
- Pin-Feng Hung
- En-Ting Liu (ORCID: https://orcid.org/0009-0007-7993-690X)
- Ya-Pin Chen
- Hsien-Neng Huang
- Wen-Tsan Weng
- Tai-Lung Cha
- Chia-Huei Lee
- Yi-Ta Tsai
- Hau-Lun Cheng
- Chiao-Yin Sun
Institutions
- National Health Research Institutes (TW)
- National Taiwan University (TW)
- Keelung Chang Gung Memorial Hospital (TW)
- National Taiwan University Hospital (TW)
- National Defense Medical Center (TW)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2026-01-03
- DOI
- https://doi.org/10.1186/s12964-025-02607-z
- Primary Topic
- Genomics and Chromatin Dynamics
- Type
- article
- Field-Weighted Citation Impact
- 0.00