Carriers of LRRK2 pathogenic variants show a milder, anatomically distinct brain signature of Parkinson’s disease
Our findings highlight genetic avenues for distinguishing PD subtypes, which could lead to more targeted treatment approaches and a more complete understanding of Parkinson's disease progression.
Authors
- Jakub Kopál (ORCID: https://orcid.org/0000-0002-1201-2872)
- Alain Dagher
- Danilo Bzdok
- Tanya Simuni
- Andrew Vo
- Qin Tao
- Lana M. Chahine
Institutions
- Northwestern University (US)
- Montreal Neurological Institute and Hospital (CA)
- University of Pittsburgh (US)
- University of Oslo (NO)
- Mila - Quebec Artificial Intelligence Institute (CA)
- McGill University (CA)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-01-03
- DOI
- https://doi.org/10.1038/s43856-025-01330-7
- Citations
- 1
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 39.15