Epigenetic mechanisms affected by stress during adolescence and the increased risk for depression later in life: a systematic review

Overall, our systematic review provides early suggestive evidence on the role of epigenetic mechanisms in mediating the effects of SLE in adolescence and the consequent onset of depression-relevant symptoms in later life. However, the paucity and the heterogeneity of the findings highlight the need for additional studies to address this fundamental research question and provide solid evidence for causality.

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Publication Details

Journal
Molecular Psychiatry
Published
2026-01-03
DOI
https://doi.org/10.1038/s41380-025-03414-1
Citations
1
Primary Topic
Epigenetics and DNA Methylation
Type
article
Field-Weighted Citation Impact
22.24

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article

Epigenetic mechanisms affected by stress during adolescence and the increased risk for depression later in life: a systematic review

Nadia Cattane, Marta Da Pian, Giulia Treccani, Patrizia Genini et al.
1 citations
Molecular Psychiatry
Epigenetics and DNA Methylation
22.24
article

Epigenetic mechanisms affected by stress during adolescence and the increased risk for depression later in life: a systematic review

Nadia Cattane, Marta Da Pian, Giulia Treccani, Patrizia Genini, Annamaria Cattaneo, Giulia Poggi
article en
1 citations

Abstract

Overall, our systematic review provides early suggestive evidence on the role of epigenetic mechanisms in mediating the effects of SLE in adolescence and the consequent onset of depression-relevant symptoms in later life. However, the paucity and the heterogeneity of the findings highlight the need for additional studies to address this fundamental research question and provide solid evidence for causality.

Molecular Psychiatry
RELX Group (Netherlands) (NL), Philipps University of Marburg (DE), University of Milan (IT), Johannes Gutenberg University Mainz (DE), University Medical Center of the Johannes Gutenberg University Mainz (DE), Centro San Giovanni di Dio Fatebenefratelli (IT), Istituti di Ricovero e Cura a Carattere Scientifico (IT), University Psychiatric Hospital (SI)
McGill University, Universität Zürich
Openalex Percentile: Top 3%
Epigenetics and DNA Methylation
22.24
DOIOpen Access PDFOpenAlex
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Epigenetic mechanisms affected by stress during adolescence and the increased risk for depression later in life: a systematic review — Nadia Cattane, Marta Da Pian, et al. · Molecular Psychiatry (2026) | TGRS Research Map | TGRS