Ten-Year Risk of Primary Malignant Brain Tumors After Buprenorphine vs Naltrexone Exposure: A Retrospective Cohort Study Using the Epic Cosmos Database
Buprenorphine and naltrexone were associated with comparable overall 10-year PMBT risk among adults with opioid-related diagnoses. The sex-specific interaction suggests naltrexone may be associated with reduced PMBT incidence in women, warranting further investigation. These findings contribute to the long-term neuro-oncologic safety profiles of opioid use disorder treatments.
Authors
- J. Meyer (ORCID: https://orcid.org/0000-0003-3899-2589)
- Damisi Akinpelu
- Riyad Abdalla
- Kevin W. Hoffman (ORCID: https://orcid.org/0000-0001-7213-5711)
- Rima Abram
Institutions
- Baylor College of Medicine (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-01-02
- DOI
- https://doi.org/10.64898/2025.12.31.25343282
- Primary Topic
- Cancer, Stress, Anesthesia, and Immune Response
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institutes of Health
- National Cancer Institute