Concomitant radiation therapy and trastuzumab deruxtecan in metastatic breast cancer: feasibility, safety, and outcomes from a real-life multicentre international cohort
Concomitant administration of T-DXd and RT appears feasible and well tolerated, without increased risk of severe or treatment-limiting toxicity. These real-world findings support the safety of this combination and warrant confirmation in prospective studies.
Authors
- Andrea Rampini
- Carlotta Becherini (ORCID: https://orcid.org/0000-0002-0597-7537)
- N. Bertini
- Chiara Mattioli (ORCID: https://orcid.org/0000-0002-1584-1991)
- Jacopo Nori Cucchiari (ORCID: https://orcid.org/0009-0009-0763-3381)
- Valentina Guarneri (ORCID: https://orcid.org/0000-0002-2375-8397)
- Luca Visani (ORCID: https://orcid.org/0000-0002-7079-231X)
- Marianna Valzano
- Rupert A. Bartsch
- C. Saieva
- Domen Ribnikar (ORCID: https://orcid.org/0000-0001-5146-4524)
- Viola Salvestrini (ORCID: https://orcid.org/0000-0002-9793-500X)
- Ivica Ratosa
- Lorenzo Orzalesi
- Icro Meattini
- Gaia Griguolo
- Lorenzo Livi
- Barbro Linderholm
- Matteo Lambertini
- Simonetta Bianchi
- Angelika M. Starzer
- Peter Kus
Institutions
- Sahlgrenska University Hospital (SE)
- Ljubljana University Medical Centre (SI)
- Institute of Oncology Ljubljana (SI)
- Istituto Oncologico Veneto (IT)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- University Clinical Centre Maribor (SI)
- Ospedale Policlinico San Martino (IT)
- Piedmont Reference Center for Epidemiology and Cancer Prevention (IT)
- University of Florence (IT)
- Medical University of Vienna (AT)
Publication Details
- Journal
- The Breast
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1016/j.breast.2026.104691
- Citations
- 1
- Primary Topic
- Breast Cancer Treatment Studies
- Type
- article
- Field-Weighted Citation Impact
- 24.82