Synchrony between brain age and internalising and externalising symptoms across adolescence

These results indicate that adolescent development of mental health problems is more strongly linked to nonlinear changes in how individuals diverge from age-expected brain trajectories, rather than to fixed differences in brain age. Shifts in brain maturational tempo may therefore be a key feature underlying vulnerability to psychopathology in youth.

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Publication Details

Journal
medRxiv
Published
2026-01-02
DOI
https://doi.org/10.64898/2025.12.31.25343265
Primary Topic
Functional Brain Connectivity Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Synchrony between brain age and internalising and externalising symptoms across adolescence

Eira Ranheim Aksnes, Niamh MacSweeney, Chloe Carrick, Delia Fuhrmann et al.
medRxiv
Functional Brain Connectivity Studies
article

Synchrony between brain age and internalising and externalising symptoms across adolescence

Eira Ranheim Aksnes, Niamh MacSweeney, Chloe Carrick, Delia Fuhrmann, Dani Beck, Christian K Tamnes, Lars T. Westlye
article en

Abstract

These results indicate that adolescent development of mental health problems is more strongly linked to nonlinear changes in how individuals diverge from age-expected brain trajectories, rather than to fixed differences in brain age. Shifts in brain maturational tempo may therefore be a key feature underlying vulnerability to psychopathology in youth.

medRxiv
Oslo University Hospital (NO), King's College London (GB), University of Oslo (NO), Diakonhjemmet Hospital (NO)
Openalex Percentile: Top 98%
Functional Brain Connectivity Studies
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Synchrony between brain age and internalising and externalising symptoms across adolescence — Eira Ranheim Aksnes, Niamh MacSweeney, et al. · medRxiv (2026) | TGRS Research Map | TGRS