Real-world comparative effectiveness of sarilumab versus Janus kinase inhibitors as monotherapy in rheumatoid arthritis
SAR and JAKi showed no statistically significant differences in 12-month retention or disease control in MTX-free monotherapy settings. Higher CRP and Plt with lower Hb, particularly in younger patients, identified better response to SAR and support biomarker guided selection between IL-6Ri and JAKi. In Phase 2, GC discontinuation with SAR suggests a practical strategy to reduce AEs while maintaining efficacy. Prospective studies should validate these findings and define actionable thresholds.
Authors
- Hirofumi Miyake (ORCID: https://orcid.org/0000-0001-5655-6356)
- Yumiko Wada
- Tohru Takeuchi (ORCID: https://orcid.org/0000-0002-0065-929X)
- K. Mamoto (ORCID: https://orcid.org/0000-0002-7541-3745)
- Yuji Nozaki (ORCID: https://orcid.org/0000-0003-2810-1519)
- Kazuya Kishimoto
- T. Okano (ORCID: https://orcid.org/0000-0002-0873-5728)
- Tadashi Okano (ORCID: https://orcid.org/0000-0002-8849-9824)
- Tetsu Itami (ORCID: https://orcid.org/0009-0000-9991-4176)
- J. Saegusa
- Takuya Kotani (ORCID: https://orcid.org/0000-0003-2190-0780)
- Masahiro Horita (ORCID: https://orcid.org/0000-0002-9360-6081)
- Shoichi Hino
- Kazuhiro Hatta
- Toshihiko Hidaka (ORCID: https://orcid.org/0000-0002-9919-1964)
- Yutaro Yamada
- Keiichiro Nishida
- Toshiaki Miyamoto
- Shinya Rai
- Koji Kinoshita (ORCID: https://orcid.org/0000-0003-1809-5143)
- Daisuke Tomita
Institutions
- Yazaki (United States) (US)
- Okayama University (JP)
- Spinal Cord Injury BC (CA)
- Tenri Hospital (JP)
- Kindai University Hospital (JP)
- Seirei Hamamatsu General Hospital (JP)
- Izumi City General Hospital (JP)
- University of Miyazaki Hospital (JP)
- Hamamatsu Medical Center (JP)
- Osaka Metropolitan University (JP)
- Kobe University (JP)
- Osaka University of Pharmaceutical Sciences (JP)
- Kindai University (JP)
Publication Details
- Journal
- Arthritis Research & Therapy
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1186/s13075-025-03722-5
- Primary Topic
- Rheumatoid Arthritis Research and Therapies
- Type
- article
- Field-Weighted Citation Impact
- 0.00