The traffic controller: GARLH4 dictates neuroligin synapse-type preference
Neuroligin isoforms are commonly thought to intrinsically specify synapse identity. In this issue, Yamasaki et al. (https://doi.org/10.1083/jcb.202507190) show that the auxiliary protein GARLH4 (LHFPL4) instead dictates neuroligin preference via competitive hierarchy, enabling dynamic reassignment between excitatory and inhibitory postsynaptic domains.
Authors
- E. Kim
Institutions
- Korea Advanced Institute of Science and Technology (KR)
- Institute for Basic Science (KR)
Publication Details
- Journal
- The Journal of Cell Biology
- Published
- 2025-12-23
- DOI
- https://doi.org/10.1083/jcb.202512185
- Primary Topic
- Neuroscience and Neuropharmacology Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00