Early effects of cigarette smoke on adolescent endothelial functions: a novel endocan/cotinine ratio approach
Cigarette smoke exposure in adolescents leads to elevated cotinine levels and increased blood pressure (p=0.03), indicating early vascular changes. The observed negative correlation between cotinine and endocan levels (r=-0.435, p=0.003) may reflect a compensatory endothelial response. The endocan/cotinine ratio could serve as a novel, early biomarker for endothelial dysfunction in youth exposed to cigarette smoke.
Authors
- Ayşe Didem Kiliç (ORCID: https://orcid.org/0000-0002-6804-6764)
- Mustafa Özçetin (ORCID: https://orcid.org/0000-0003-0697-4271)
- Elnur Karimov
- Elanur Yolal Karimov
- Kazım Okan Dolu
Institutions
- Teknoloji Arastirma ve Gelistirme Endustriyel Urunler Bilisim Teknolojileri San Tic (TR)
- İstanbul Kanuni Sultan Süleyman Eğitim ve Araştırma Hastanesi (TR)
- Istanbul University (TR)
- University of Health Sciences Antigua (AG)
Publication Details
- Journal
- International Journal of Adolescent Medicine and Health
- Published
- 2026-01-03
- DOI
- https://doi.org/10.1515/ijamh-2025-0174
- Primary Topic
- Inflammation biomarkers and pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00