An Analysis of the Governance, Ethical, Legal, and Social Implications of Biocomputing

Biological computing (biocomputing) leverages biologically derived materials and processes, such as DNA and protein synthesis, to perform computational tasks. Biocomputing offers significant advantages over traditional silicon-based systems in terms of scalability, energy efficiency, computational flexibility, and information storage potential. However, the distinct operational characteristics of biocomputing raise novel governance, ethical, legal, and social implications (GELSI). This article identifies and analyzes key GELSI concerns raised by biocomputing. It then highlights the inadequacies of current regulatory frameworks in addressing the unique challenges posed by massively parallel molecular computations, biosafety risks, probabilistic error management in clinical applications, patentability of biological storage systems, and ownership rights in self-replicating data systems. The analysis concludes by recommending specialized regulatory approaches and international collaboration to govern biocomputing technologies responsibly, ensuring their ethical integration and equitable benefits across global societies.

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Journal
Science and Engineering Ethics
Published
2026-01-02
DOI
https://doi.org/10.1007/s11948-025-00572-x
Primary Topic
Genetics, Bioinformatics, and Biomedical Research
Type
article
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article

An Analysis of the Governance, Ethical, Legal, and Social Implications of Biocomputing

Renée Sirbu, Luciano Floridi
Science and Engineering Ethics
Genetics, Bioinformatics, and Biomedical Research
article

An Analysis of the Governance, Ethical, Legal, and Social Implications of Biocomputing

Renée Sirbu, Luciano Floridi
article en

Abstract

Biological computing (biocomputing) leverages biologically derived materials and processes, such as DNA and protein synthesis, to perform computational tasks. Biocomputing offers significant advantages over traditional silicon-based systems in terms of scalability, energy efficiency, computational flexibility, and information storage potential. However, the distinct operational characteristics of biocomputing raise novel governance, ethical, legal, and social implications (GELSI). This article identifies and analyzes key GELSI concerns raised by biocomputing. It then highlights the inadequacies of current regulatory frameworks in addressing the unique challenges posed by massively parallel molecular computations, biosafety risks, probabilistic error management in clinical applications, patentability of biological storage systems, and ownership rights in self-replicating data systems. The analysis concludes by recommending specialized regulatory approaches and international collaboration to govern biocomputing technologies responsibly, ensuring their ethical integration and equitable benefits across global societies.

Science and Engineering EthicsVol. 32(1)
Yale University (US), University of Bologna (IT)
Affordable and clean energy
Openalex Percentile: Top 98%
Genetics, Bioinformatics, and Biomedical Research
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An Analysis of the Governance, Ethical, Legal, and Social Implications of Biocomputing — Renée Sirbu, Luciano Floridi · Science and Engineering Ethics (2026) | TGRS Research Map | TGRS