Anti-inflammatory and dry eye benefits of accelerated epi-off corneal cross-linking in pediatric keratoconus with allergic ocular surface disease and elevated MMP-9
Epi-off ACXL stabilized ectasia, improving visual and ocular surface outcomes, markedly lowering tear MMP-9 levels. Although exploratory, these findings are consistent with a potential ocular surface anti-inflammatory and neuromodulatory role of ACXL, meriting validation in studies involving inflammatory DED beyond keratoconus.
Authors
- F. Cappellani (ORCID: https://orcid.org/0009-0007-6807-9455)
- Cosimo Giuseppe Mazzotta (ORCID: https://orcid.org/0000-0002-1829-9288)
- Carlos Rocha‐de‐Lossada (ORCID: https://orcid.org/0000-0001-7464-2493)
- Marco Ferrise (ORCID: https://orcid.org/0000-0002-0971-8225)
- Davide Borroni (ORCID: https://orcid.org/0000-0001-6952-5647)
- Alessandro Meduri (ORCID: https://orcid.org/0000-0001-7546-9178)
- Fabiana D’Esposito
- Caterina Gagliano
Institutions
- University of Siena (IT)
- University of Messina (IT)
- Università degli Studi di Enna Kore (IT)
- Hospital Regional Universitario de Málaga (ES)
- Riga Stradiņš University (LV)
- BioAge (Italy) (IT)
- Universidad de Sevilla (ES)
Publication Details
- Journal
- Eye and Vision
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1186/s40662-025-00469-7
- Citations
- 2
- Primary Topic
- Corneal surgery and disorders
- Type
- article
- Field-Weighted Citation Impact
- 63.85