Imaging transcriptomics identifies gene signatures associated with cortical thinning in schizophrenia

This study reveals specific molecular correlates of cortical thinning in schizophrenia, highlighting biological mechanisms that may contribute to structural abnormalities. The identified genes and pathways offer potential therapeutic targets for addressing both neuroanatomical changes and affective disturbances in schizophrenia.

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Publication Details

Journal
Journal of Psychiatric Research
Published
2026-01-03
DOI
https://doi.org/10.1016/j.jpsychires.2026.01.008
Primary Topic
Schizophrenia research and treatment
Type
article
Field-Weighted Citation Impact
0.00
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article

Imaging transcriptomics identifies gene signatures associated with cortical thinning in schizophrenia

Zhiqiang Zhou, Shaodi Guan, Shenrui Li, Yueyang Xin et al.
Journal of Psychiatric Research
Schizophrenia research and treatment
article

Imaging transcriptomics identifies gene signatures associated with cortical thinning in schizophrenia

Zhiqiang Zhou, Shaodi Guan, Shenrui Li, Yueyang Xin, Ye Tu, Hong Tao, Hui Xu, Shaofang Wang, Hongwei Jiang
article en

Abstract

This study reveals specific molecular correlates of cortical thinning in schizophrenia, highlighting biological mechanisms that may contribute to structural abnormalities. The identified genes and pathways offer potential therapeutic targets for addressing both neuroanatomical changes and affective disturbances in schizophrenia.

Journal of Psychiatric ResearchVol. 194
Tongji Hospital (CN), Huazhong University of Science and Technology (CN)
Good health and well-being
Openalex Percentile: Top 97%
Schizophrenia research and treatment
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