Essential role of endothelial T-cadherin in the transcytosis of circulating high-molecular-weight adiponectin to sub-vascular tissues
These findings identify vascular endothelial T-cadherin as a key mediator of HMW adiponectin transcytosis via the recycling endosome pathway, enabling its traversal from the circulation to sub-vascular tissues/cells and offering a mechanistic basis for the systemic organ-protective effects of adiponectin.
Authors
- Yoshinari Obata (ORCID: https://orcid.org/0000-0002-3443-3635)
- Yoshihisa Koyama (ORCID: https://orcid.org/0000-0003-3965-0716)
- Keitaro Kawada (ORCID: https://orcid.org/0000-0003-4976-2121)
- HIROFUMI NAGAO
- Shiro Fukuda (ORCID: https://orcid.org/0000-0003-0712-7154)
- S. Shimada
- Yoshiaki Okada (ORCID: https://orcid.org/0000-0002-2962-244X)
- Yuya Fujishima (ORCID: https://orcid.org/0000-0003-0028-1757)
- Shunbun Kita (ORCID: https://orcid.org/0000-0002-8937-0053)
- Hitoshi Nishizawa
- Iichiro Shimomura
- Kohei Fujii
- Keita Fukuoka
- Atsuya Shirono
- Keisuke Sirakura
- Norikazu Maeda
- Yuta Kondo
- Saito Inoue
- Shunsuke Shiode (ORCID: https://orcid.org/0009-0007-7682-0602)
Institutions
- Kindai University (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Metabolism
- Published
- 2026-01-03
- DOI
- https://doi.org/10.1016/j.metabol.2025.156488
- Primary Topic
- Adipokines, Inflammation, and Metabolic Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Suzuken Memorial Foundation
- Japan Agency for Medical Research and Development
- Manpei Suzuki Diabetes Foundation
- Japan Society for the Promotion of Science
- Core Research for Evolutional Science and Technology