Association between serum uric acid levels and clinical outcomes of immunotherapy in advanced colorectal cancer patients

Elevated baseline serum UA is associated with poorer long-term survival in patients with dMMR/MSI-H advanced colorectal cancer receiving immunotherapy. As an accessible and cost-effective biomarker, UA shows potential for early risk-stratification and guiding individualized treatment strategies within this immunotherapy-sensitive population.

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Publication Details

Journal
BMC Cancer
Published
2026-01-03
DOI
https://doi.org/10.1186/s12885-025-15431-y
Primary Topic
Gout, Hyperuricemia, Uric Acid
Type
article
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article

Association between serum uric acid levels and clinical outcomes of immunotherapy in advanced colorectal cancer patients

Mingchen Shao, Sufeng Fan, Wang Ma
BMC Cancer
Gout, Hyperuricemia, Uric Acid
article

Association between serum uric acid levels and clinical outcomes of immunotherapy in advanced colorectal cancer patients

Mingchen Shao, Sufeng Fan, Wang Ma
article en

Abstract

Elevated baseline serum UA is associated with poorer long-term survival in patients with dMMR/MSI-H advanced colorectal cancer receiving immunotherapy. As an accessible and cost-effective biomarker, UA shows potential for early risk-stratification and guiding individualized treatment strategies within this immunotherapy-sensitive population.

BMC CancerVol. 26(1)
Henan University (CN), Zhengzhou University (CN), Henan Provincial People's Hospital (CN), First Affiliated Hospital of Zhengzhou University (CN)
No poverty
Openalex Percentile: Top 99%
Gout, Hyperuricemia, Uric Acid
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