Bisphenol F induces oxidative stress and hematotoxicity in male rats

Among the bisphenol A analogues, is bisphenol F (BPF), which is widely used in plastic, epoxy resin, and consumer product production. The current research aimed at exploring the negative effects that bisphenol F (BPF) has on the hematological parameters, erythrocyte fragility, and oxidative stress status in erythrocytes and serum samples. Male Wistar albino rats (n = 28) were assigned randomly to the vehicle control (VC), BPF-20, BPF-100, and BPF-500 groups, with seven in each. The VC group was given only the vehicle, while the BPF-20, BPF-100, and BPF-500 groups had oral gavage administration of BPF at dosages of 20, 100, and 500 mg/kg of body weight, respectively, for 28 days. The results revealed significant decreases in the red blood cell (RBC) count, hemoglobin (HGB) level, and hematocrit value in the BPF-500 group. The mean corpuscular volume was increased in the BPF-20 and BPF-100 groups, while the mean corpuscular HGB concentration was increased in all the BPF groups. A significant decrease was seen in the differential lymphocyte count, while significant increases in the differential neutrophil and monocyte counts were noted in the BPF-500 group. Platelet (PLT) indices, including the PLT distribution width, PLT large cell ratio, and mean PLT volume, displayed significant decreases. Significant increases were found in the percentage of hemolysis of the RBCs in the BPF-500 group. The reduced glutathione content was decreased, whereas the malondialdehyde level increased significantly in the erythrocytes and serum samples with the BPF dosages of 100 and 500 mg/kg/day. Bisphenol F causes adverse effects on hematological parameters and induces erythrocyte osmotic fragility and oxidative stress in male rats at sublethal doses.