Continuous Infusion of Aztreonam–Avibactam After High Loading Dose for an Infection Caused by an OXA-48- and NDM-1-Co-producing ST147 Klebsiella pneumoniae
CI of ATM-AVI following a high loading dose was feasible, safe, and allowed optimized pharmacokinetic/pharmacodynamic (PK/PD) exposure while preventing drug wastage. Larger studies are warranted to determine the clinical utility of CI ATM-AVI across different MIC ranges.
Authors
- Alix Pantel (ORCID: https://orcid.org/0000-0002-2317-4199)
- P Laffont-Lozes
- Romaric Larcher (ORCID: https://orcid.org/0000-0002-7591-0901)
- Albert Sotto (ORCID: https://orcid.org/0000-0002-6463-9386)
- Fanny Villa
- Céline Mory
- Paul Loubet
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Université de Montpellier (FR)
- Centre Hospitalier Universitaire de Nîmes (FR)
- Hôpital Paris Saint-Joseph (FR)
- Université de Nîmes (FR)
Publication Details
- Journal
- Infectious Diseases and Therapy
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1007/s40121-025-01294-0
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00