Cell-free RNA profiling uncovers non-canonical circulating D2 transcript elevation in Bladder Cancer plasma
These findings demonstrate that D2 is detectably elevated in the circulation of BLCA patients and captures tumor-associated transcriptional alterations that are independent of established urothelial markers. The distinct, non-redundant behavior of circulating D2 supports its potential value as a complementary biomarker for minimally invasive molecular profiling of BLCA. Further studies are required to define its diagnostic performance and clinical applicability.
Authors
- P Conforti
- Monica Dentice (ORCID: https://orcid.org/0000-0002-9977-3761)
- Daniela Terracciano (ORCID: https://orcid.org/0000-0003-4296-429X)
- Caterina Miro (ORCID: https://orcid.org/0000-0002-1008-8443)
- Annarita Nappi (ORCID: https://orcid.org/0000-0002-0876-3323)
- Serena Sagliocchi (ORCID: https://orcid.org/0000-0003-0796-1392)
- Annunziata Gaetana Cicatiello (ORCID: https://orcid.org/0000-0002-6008-7086)
- R. La Rocca
- Lucia Acampora (ORCID: https://orcid.org/0009-0001-8220-4212)
- Francesco Del Giudice (ORCID: https://orcid.org/0000-0003-3865-5988)
- Federica Restolfer (ORCID: https://orcid.org/0009-0001-3417-1575)
- Rosa Sirica (ORCID: https://orcid.org/0009-0006-3629-476X)
- Lorenzo Spirito
- Silvia Del Mastro
- Felice Crocetto
Institutions
- Federico II University Hospital (IT)
- University of Campania "Luigi Vanvitelli" (IT)
- CEINGE Biotecnologie Avanzate Franco Salvatore (Italy) (IT)
- University of Naples Federico II (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- The Journal of Liquid Biopsy
- Published
- 2026-01-03
- DOI
- https://doi.org/10.1016/j.jlb.2025.100454
- Primary Topic
- Bladder and Urothelial Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministero dell’Istruzione, dell’Università e della Ricerca
- Associazione Italiana per la Ricerca sul Cancro