Carcinoma Ex Pleomorphic Adenoma of the Palate in a Young Female: A Rare and Aggressive Malignant Transformation

Abstract Carcinoma ex pleomorphic adenoma (CXPA) is an uncommon malignant salivary gland tumor that develops from a preexisting pleomorphic adenoma (PA). It accounts for roughly 3.6% of all salivary gland neoplasms. While it commonly occurs in older individuals, especially in the parotid gland, intraoral presentation in a young patient is uncommon and poses a diagnostic challenge. We report a case of a 28-year-old female diagnosed with CXPA in the palatal region. The lesion gradually increased in size, became painful and ulcerated. Histopathological examination confirmed the diagnosis of CXPA. The patient underwent surgical excision followed by postoperative radiotherapy. This case highlights the importance of early intervention in benign salivary gland tumors to prevent malignant transformation. This report describes a rare case of CXPA arising in a young female involving the minor salivary glands. The report follows CARE guidelines, presenting chronological history, diagnosis, management, follow-up, patient perspective, and ethical statement.