Therapeutic potential of β-sitosterol in methotrexate-induced liver injury: association with STING and ERK-1 pathways
β-sitosterol was associated with reduced oxidative stress markers and lower hepatic TGF-β, STING and ERK-1 levels in this short-term MTX injury model. These findings suggest that β-sitosterol may have potential therapeutic value in mitigating MTX-related hepatotoxicity.
Authors
- Oytun Erbaş (ORCID: https://orcid.org/0000-0001-5427-8428)
- Mümin Alper Erdoğan (ORCID: https://orcid.org/0000-0003-0048-444X)
- Özkan ŞİMŞEK (ORCID: https://orcid.org/0000-0003-3340-9382)
- Mustafa Yıldız (ORCID: https://orcid.org/0000-0001-5833-7499)
- Mehmet Ulusan
- Bertug Bekir Ciftci
- Mesih Kocamuftuoglu
Institutions
- Çanakkale Onsekiz Mart Üniversitesi (TR)
- Izmir Kâtip Çelebi University (TR)
- Biruni University (TR)
- Istanbul Eye Hospital (TR)
- Burdur Mehmet Akif Ersoy Üniversitesi (TR)
Publication Details
- Journal
- BMC Gastroenterology
- Published
- 2026-01-03
- DOI
- https://doi.org/10.1186/s12876-025-04587-3
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00