Evaluation of trained immunity as a potential strategy for a universal Streptococcus suis vaccine using immunogenic proteins in a murine model
These findings suggest complementary roles for live and inactivated dpB in innate and adaptive immunity. This approach may represent an initial step towards improving vaccine efficacy against S. suis, combining targeted innate with adaptive immunity. Further research is needed to optimize combinations of immunomodulators with traditional S. suis antigens.
Authors
- Dominguez Mercedes
- Moreno Inmaculada
- Marta Díaz-Frutos
- Andrea Pérez-Domingo (ORCID: https://orcid.org/0000-0002-0560-022X)
- Sergio Ciordia (ORCID: https://orcid.org/0000-0002-5726-853X)
- Teresa García‐Seco (ORCID: https://orcid.org/0000-0002-6162-1025)
- Pérez-Sancho Marta
- Lucas Domínguez
- Aranzazu Garcia Buendia
- Lidia Sánchez-Morales
- María de los Ángeles Risalde
- Leydis Zamora
Institutions
- Universidad Complutense de Madrid (ES)
- Instituto de Salud Carlos III (ES)
- Centro Nacional de Microbiologia (ES)
- Centro Nacional de Biotecnología (ES)
- Department of Animal Health (VN)
- University of Córdoba (ES)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1186/s12917-025-05228-3
- Primary Topic
- Immune responses and vaccinations
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Banco Santander
- Universidad Complutense de Madrid
- Agencia Estatal de Investigación