Antiphospholipid Antibodies in Severe COVID-19: Frequency, Clinical Features, and 12-Week Follow-Up

We detected APLAs in one third of patients with severe COVID-19; however, they were not associated with clinical thromboembolic events and decreased markedly over time. These findings indicate that APLA responses during acute COVID-19 are largely transient and may not be useful for predicting thrombotic risk. Our findings do not support routine APLA testing during the acute phase of COVID-19.

Authors

Chowdhury Adnan Sami (ORCID: https://orcid.org/0000-0001-6816-4085)
Kazi Mohammad Kamrul Islam (ORCID: https://orcid.org/0000-0001-9298-0023)
Md. Tanvir Islam (ORCID: https://orcid.org/0000-0002-8604-1035)
Md. Nazmul Hasan
Fazle R Chowdhury

Institutions

Bangladesh Medical University (BD)
University of Dhaka (BD)
Dhaka Medical College and Hospital (BD)

Publication Details

Journal: Cureus
Published: 2026-01-03
DOI: https://doi.org/10.7759/cureus.100657
Primary Topic: COVID-19 Clinical Research Studies
Type: article
Field-Weighted Citation Impact: 0.00

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article

Antiphospholipid Antibodies in Severe COVID-19: Frequency, Clinical Features, and 12-Week Follow-Up

Chowdhury Adnan Sami, Kazi Mohammad Kamrul Islam, Md. Tanvir Islam, Md. Nazmul Hasan et al.

Jan 3, 2026

Cureus

COVID-19 Clinical Research Studies

article

Antiphospholipid Antibodies in Severe COVID-19: Frequency, Clinical Features, and 12-Week Follow-Up

Chowdhury Adnan Sami, Kazi Mohammad Kamrul Islam, Md. Tanvir Islam, Md. Nazmul Hasan, Fazle R Chowdhury

January 3, 2026article en

Abstract

We detected APLAs in one third of patients with severe COVID-19; however, they were not associated with clinical thromboembolic events and decreased markedly over time. These findings indicate that APLA responses during acute COVID-19 are largely transient and may not be useful for predicting thrombotic risk. Our findings do not support routine APLA testing during the acute phase of COVID-19.

CureusVol. 18(1)

Bangladesh Medical University (BD), University of Dhaka (BD), Dhaka Medical College and Hospital (BD)

Good health and well-being

Openalex Percentile: Top 99%

COVID-19 Clinical Research Studies

DOI Open Access PDF OpenAlex

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