Iceberg phenomenon in cutaneous leishmaniasis: A sporotrichoid clue

We present a 29-year-old immunocompetent Uzbek woman with an ulcerated nodular lesion on her arm following an insect bite, caused by Leishmania major and confirmed by polymerase chain reaction (RT-PCR). The patient was initially treated with oral itraconazole and topical imiquimod. However, the disease progressed over 3 months and systemic liposomal amphotericin B was subsequently initiated. Magnetic resonance imaging (MRI) revealed deep tissue involvement, marking the first such finding in sporotrichoid cutaneous leishmaniasis caused by L major. This case emphasises the diagnostic and treatment challenges of atypical cutaneous leishmaniasis and highlights the value of imaging techniques in assessing disease extent.

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Publication Details

Journal
Clinical Medicine
Published
2026-01-02
DOI
https://doi.org/10.1016/j.clinme.2025.100551
Primary Topic
Research on Leishmaniasis Studies
Type
article
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article

Iceberg phenomenon in cutaneous leishmaniasis: A sporotrichoid clue

Mustafa Ozates, Gokhan Okan
Clinical Medicine
Research on Leishmaniasis Studies
article

Iceberg phenomenon in cutaneous leishmaniasis: A sporotrichoid clue

Mustafa Ozates, Gokhan Okan
article en

Abstract

We present a 29-year-old immunocompetent Uzbek woman with an ulcerated nodular lesion on her arm following an insect bite, caused by Leishmania major and confirmed by polymerase chain reaction (RT-PCR). The patient was initially treated with oral itraconazole and topical imiquimod. However, the disease progressed over 3 months and systemic liposomal amphotericin B was subsequently initiated. Magnetic resonance imaging (MRI) revealed deep tissue involvement, marking the first such finding in sporotrichoid cutaneous leishmaniasis caused by L major. This case emphasises the diagnostic and treatment challenges of atypical cutaneous leishmaniasis and highlights the value of imaging techniques in assessing disease extent.

Clinical MedicineVol. 26(2)
Istanbul Aydın University (TR), Advanced Imaging Research (United States) (US)
Good health and well-being
Openalex Percentile: Top 99%
Research on Leishmaniasis Studies
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