Extracellular vesicles derived from adipose-derived mesenchymal stem/stromal cells prevent synovial inflammation and attenuate cartilage degeneration in rodent osteoarthritis
MSC-EVs exert anti-inflammatory and cartilage-protective effects in OA through immune modulation and regenerative signaling, indicating their significant therapeutic potential as a disease-modifying strategy for OA.
Authors
- Akihito Oya (ORCID: https://orcid.org/0000-0001-9832-1491)
- Yasuo Niki
- Yoshitsugu Fukuda
- Shu Kobayashi
- Atsuhiro Fujie
- Satoshi Kuronuma
- Yo Mabuchi
- Yushi Maruiwa
- Masaya Nakamura
- Osamu Takeuchi
Institutions
- Fujita Health University (JP)
- Keio University (JP)
- Kitasato Institute Hospital (JP)
Publication Details
- Journal
- Regenerative Therapy
- Published
- 2026-01-03
- DOI
- https://doi.org/10.1016/j.reth.2025.101056
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.00