Novel Substituted Benzisoxazole Sulfonamides as Lysine Acetyl Transferase Inhibitors for the Treatment of Cancers
This patent describes novel substituted benzisoxazole sulfonamides as lysine acetyl transferase (KAT) inhibitors with potential applications in cancer therapy. It provides details on the synthesis of novel substituted benzisoxazole sulfonamides, their pharmaceutical composition, and the use in the treatment of cancers.
Authors
- Steven H. Liang (ORCID: https://orcid.org/0000-0003-1413-6315)
- Jian Rong (ORCID: https://orcid.org/0009-0000-6505-1624)
Institutions
- Georgia Institute of Technology (US)
- Emory University (US)
- The Wallace H. Coulter Department of Biomedical Engineering (US)
- Union Hospital (CN)
Publication Details
- Journal
- ACS Medicinal Chemistry Letters
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1021/acsmedchemlett.5c00745
- Primary Topic
- Enzyme function and inhibition
- Type
- article
- Field-Weighted Citation Impact
- 0.00