Radiobiological investigations of a [ <sup>212</sup> Pb]Pb-carbonic anhydrase IX-targeting small-molecule ligand in renal cell carcinoma and colorectal cancer models
These findings highlight the potential of CAIX-targeted alpha therapy. CAIX expression and receptor density impact binding affinity and therapeutic response. The study demonstrates the importance of 3D tumor models in evaluating alpha-particle cross-fire effects. Further ligand optimization is warranted to enhance tumor specificity and minimize off-target uptake.
Authors
- Asta Juzeniene (ORCID: https://orcid.org/0000-0001-9426-0062)
- Øyvind S. Bruland (ORCID: https://orcid.org/0000-0003-1631-3733)
- K. A. Shubin
- Daumantas Matulis
- Petras Juzenas
- Sandra K. Kristiansen
- Asta Zubrienė
- Nurtene Dernjani
Institutions
- Vilnius University (LT)
- University of Oslo (NO)
- Norwegian Cancer Society (NO)
- Czech Academy of Sciences, Institute of Biotechnology (CZ)
- Latvijas Organiskās Sintēzes Institūts (LV)
- Institute of Organic Synthesis (RU)
- Norwegian University of Life Sciences (NO)
Publication Details
- Journal
- International Journal of Radiation Biology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1080/09553002.2025.2595630
- Primary Topic
- Enzyme function and inhibition
- Type
- article
- Field-Weighted Citation Impact
- 0.00