Busulfan inhibits Pseudomonas aeruginosa growth and reduces biofilm biomass and pyocyanin production
Overall, busulfan demonstrates antimicrobial activity against <i>P. aeruginosa</i>, particularly through its effects on virulence factors. These preliminary results support the potential value of busulfan for repurposing, although further studies are needed to clarify its mechanism and therapeutic relevance.
Authors
- Terrence S. Sumague (ORCID: https://orcid.org/0000-0001-5367-9967)
- Rhodanne Nicole A. Lambarte (ORCID: https://orcid.org/0000-0001-7978-3674)
- Turki M. Dawoud (ORCID: https://orcid.org/0000-0002-5945-1776)
- Abdurahman A. Niazy (ORCID: https://orcid.org/0000-0003-0493-3601)
- Khalid S. Almaary (ORCID: https://orcid.org/0009-0006-6745-8480)
- Needa A. Bahkali
Institutions
- King Saud bin Abdulaziz University for Health Sciences (SA)
- King Saud University (SA)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.3389/fcimb.2025.1721773
- Primary Topic
- Antimicrobial agents and applications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- King Saud University
- King Fahad Medical City
- College of Dentistry, King Saud University