Single-cell RNA sequencing unraveled immune-related expression heterogeneity and lymphoid cell development dysregulation in childhood asthma

Our scRNA-Seq analyses unveil childhood asthma as a complex disease with immune-related heterogenicities, characterized by dysregulated lymphoid cell development, a common feature that may offer a novel research direction for comprehensively understanding the key molecular mechanisms underlying childhood asthma.

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Publication Details

Journal
Frontiers in Immunology
Published
2026-01-02
DOI
https://doi.org/10.3389/fimmu.2025.1606650
Primary Topic
IL-33, ST2, and ILC Pathways
Type
article
Field-Weighted Citation Impact
0.00
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article

Single-cell RNA sequencing unraveled immune-related expression heterogeneity and lymphoid cell development dysregulation in childhood asthma

Chao Wang, Libing Shen, Danying Zhu, Zeyu Zeng et al.
Frontiers in Immunology
IL-33, ST2, and ILC Pathways
article

Single-cell RNA sequencing unraveled immune-related expression heterogeneity and lymphoid cell development dysregulation in childhood asthma

Chao Wang, Libing Shen, Danying Zhu, Zeyu Zeng, Na Dong, G X Ding, Lijian Xie, Xiaoyan Dong, Guang Li, Lang Yuan, Ming Chen
article en

Abstract

Our scRNA-Seq analyses unveil childhood asthma as a complex disease with immune-related heterogenicities, characterized by dysregulated lymphoid cell development, a common feature that may offer a novel research direction for comprehensively understanding the key molecular mechanisms underlying childhood asthma.

Frontiers in ImmunologyVol. 16
Fudan University (CN), Shanghai University of Traditional Chinese Medicine (CN), Jinshan Hospital of Fudan University (CN), Longhua Hospital Shanghai University of Traditional Chinese Medicine (CN), Hongzhiwei Technology (China) (CN), Shanghai Children's Hospital (CN)
Openalex Percentile: Top 98%
IL-33, ST2, and ILC Pathways
DOIOpen Access PDFOpenAlex
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