Complement-mediated and direct activation of human neutrophils induced by Premolis semirufa caterpillar toxins
These findings highlight the integrated role of complement in neutrophil activation, as compstatin broadly inhibited complement-dependent effects, while PMX205 demonstrated the specific contribution of the C5a-C5aR1 axis. Targeting complement thus emerges as a promising strategy to mitigate inflammation and tissue damage in affected individuals.
Authors
- Giselle Pidde
- Denise V. Tambourgi (ORCID: https://orcid.org/0000-0003-1896-9074)
- Joel J. M. Gabrili
- Ângela A. A. Megale
- Trent M. Woodruff
Institutions
- The University of Queensland (AU)
- Instituto Butantan (BR)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1706235
- Primary Topic
- Entomological Studies and Ecology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Conselho Nacional de Desenvolvimento Científico e Tecnológico