Role of SUV39H2 in shaping the malignant phenotype of triple-negative breast cancer
SUV39H2 is consistently upregulated in triple-negative breast cancer and is associated with malignant features including enhanced proliferation, migration, stemness, and <i>in vivo</i> tumorigenicity. Functional and clinical evidence highlights SUV39H2 as a potential diagnostic biomarker and therapeutic target in TNBC, although its clinical utility requires further validation.
Authors
- Yang Deng (ORCID: https://orcid.org/0009-0006-0825-9596)
- Shuang Hu
- Zhi-Wen Wang
- Hai-Tao Jiang
- Yong Chen
- Shang-Fu Li
- Yong Lu
Institutions
- Jianghan University (CN)
- Yueyang Second People's Hospital (CN)
- Yueyang Changling Equipment Research Institute (China) (CN)
- Puyang Vocational and Technical College (CN)
- Wuhan University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.3389/fonc.2025.1679640
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Hunan Province