Impacts of rs7528684 (−169T/C) on FCRL3, FOXP3, and IL-35 gene expressions and IgG-RF correlation: insights into the pathogenesis of rheumatoid arthritis

Our findings validate that the C/C genotype of the <i>FCRL3</i> SNP rs7528684 is strongly associated with RA in the Indian ethnicity. This genotype is characterised by positive IgG-RF and upregulated <i>FCRL3</i> and downregulated <i>FOXP3</i> and <i>IL-35</i> as key anti-inflammatory cytokines. Concurrently, <i>FCRL3</i> and <i>FOXP3</i> mRNA expression levels are inversely correlated.

Authors

Institutions

Publication Details

Journal
Frontiers in Genetics
Published
2026-01-02
DOI
https://doi.org/10.3389/fgene.2025.1720056
Primary Topic
T-cell and B-cell Immunology
Type
article
Field-Weighted Citation Impact
0.00

Funders

Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Impacts of rs7528684 (−169T/C) on FCRL3, FOXP3, and IL-35 gene expressions and IgG-RF correlation: insights into the pathogenesis of rheumatoid arthritis

S. Mohamed Muzammil, S. Asha Devi
Frontiers in Genetics
T-cell and B-cell Immunology
article

Impacts of rs7528684 (−169T/C) on FCRL3, FOXP3, and IL-35 gene expressions and IgG-RF correlation: insights into the pathogenesis of rheumatoid arthritis

S. Mohamed Muzammil, S. Asha Devi
article en

Abstract

Our findings validate that the C/C genotype of the <i>FCRL3</i> SNP rs7528684 is strongly associated with RA in the Indian ethnicity. This genotype is characterised by positive IgG-RF and upregulated <i>FCRL3</i> and downregulated <i>FOXP3</i> and <i>IL-35</i> as key anti-inflammatory cytokines. Concurrently, <i>FCRL3</i> and <i>FOXP3</i> mRNA expression levels are inversely correlated.

Frontiers in GeneticsVol. 16
Vellore Institute of Technology University (IN)
VIT University
Openalex Percentile: Top 98%
T-cell and B-cell Immunology
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.