Integrative proteomics and metabolomics analysis of the mechanism of pancreatic β-cell dysfunction in aged mice
These findings suggest that concurrent endogenous protein and metabolite disturbances occur in the pancreas of aged mice, and metabolite aspartate and glutamine may serve as potential biomarkers and therapeutic targets for aging-related pancreatic dysfunction.
Authors
- Can Rong
- Fenghui Pan
- Yun Hu
- Long Wang
- Xuan He
Institutions
- Soochow University (CN)
- Jiangsu Vocational College of Medicine (CN)
- Nanjing Drum Tower Hospital (CN)
- Second Affiliated Hospital of Soochow University (CN)
Publication Details
- Journal
- Frontiers in Endocrinology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.3389/fendo.2025.1723927
- Primary Topic
- Metabolomics and Mass Spectrometry Studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province