Radiolabeled para-I-nimesulide: an unexpected tracer for imaging peripheral inflammation
These findings indicate that while [<sup>125</sup>I]<i>para</i>-I nimesulide has limited potential for brain-targeted COX-2 imaging, it may serve as a promising tracer for detecting COX-2 expression in peripheral tissues. Importantly, this study also highlighted that the electronic properties of substituents strongly influence metabolic stability, providing valuable insights for the design of future COX-2-targeted molecular imaging agents.
Authors
- Yumi Yamamoto (ORCID: https://orcid.org/0000-0002-5376-5096)
- Yohei Saito (ORCID: https://orcid.org/0000-0003-2313-8339)
- Fumihiko Yamamoto
- Kentaro Imai
Institutions
- Tohoku Medical and Pharmaceutical University (JP)
Publication Details
- Journal
- Frontiers in Nuclear Medicine
- Published
- 2026-01-02
- DOI
- https://doi.org/10.3389/fnume.2025.1720380
- Primary Topic
- Inflammatory mediators and NSAID effects
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Tohoku Medical and Pharmaceutical University
- Japan Society for the Promotion of Science