Novel 6-Aminopurine Derivatives as POLQ Inhibitors for Treating Cancer

Provided herein are novel 6-aminopurine derivatives as POLQ inhibitors, pharmaceutical compositions, use of such compounds in treating cancer, and processes for preparing such compounds.

Authors

Publication Details

Journal
ACS Medicinal Chemistry Letters
Published
2026-01-02
DOI
https://doi.org/10.1021/acsmedchemlett.5c00766
Primary Topic
Retinoids in leukemia and cellular processes
Type
article
Field-Weighted Citation Impact
0.00
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article

Novel 6-Aminopurine Derivatives as POLQ Inhibitors for Treating Cancer

Ram W. Sabnis
ACS Medicinal Chemistry Letters
Retinoids in leukemia and cellular processes
article

Novel 6-Aminopurine Derivatives as POLQ Inhibitors for Treating Cancer

Ram W. Sabnis
article en

Abstract

Provided herein are novel 6-aminopurine derivatives as POLQ inhibitors, pharmaceutical compositions, use of such compounds in treating cancer, and processes for preparing such compounds.

ACS Medicinal Chemistry LettersVol. 17(2)
Openalex Percentile: Top 98%
Retinoids in leukemia and cellular processes
DOIOpen Access PDFOpenAlex
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Novel 6-Aminopurine Derivatives as POLQ Inhibitors for Treating Cancer — Ram W. Sabnis · ACS Medicinal Chemistry Letters (2026) | TGRS Research Map | TGRS