Clinical and Histopathological Predictors of Survival in Regional Lymph Node Metastases From Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Retrospective Analysis

Metastatic cSCC of the head and neck carries a poor prognosis, even with aggressive multimodal therapy. High-risk pathological features remain key predictors of recurrence. Improved risk stratification and incorporation of novel systemic therapies may help improve long-term outcomes in this patient group.

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Publication Details

Journal
Cureus
Published
2026-01-02
DOI
https://doi.org/10.7759/cureus.100599
Primary Topic
Head and Neck Cancer Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Clinical and Histopathological Predictors of Survival in Regional Lymph Node Metastases From Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Retrospective Analysis

Esra Izeldin
Cureus
Head and Neck Cancer Studies
article

Clinical and Histopathological Predictors of Survival in Regional Lymph Node Metastases From Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Retrospective Analysis

Esra Izeldin
article en

Abstract

Metastatic cSCC of the head and neck carries a poor prognosis, even with aggressive multimodal therapy. High-risk pathological features remain key predictors of recurrence. Improved risk stratification and incorporation of novel systemic therapies may help improve long-term outcomes in this patient group.

CureusVol. 18(1)
East Kent Hospitals University NHS Foundation Trust (GB)
No poverty
Openalex Percentile: Top 99%
Head and Neck Cancer Studies
DOIOpen Access PDFOpenAlex
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Clinical and Histopathological Predictors of Survival in Regional Lymph Node Metastases From Cutaneous Squamous Cell Carcinoma of the Head and Neck: A Retrospective Analysis — Esra Izeldin · Cureus (2026) | TGRS Research Map | TGRS