Immune imbalance in the human hippocampus in PTSD revealed by single-nucleus transcriptomics
These findings demonstrate that PTSD is characterized by immune imbalance at both cellular and intercellular levels, driven by maladaptive glial activation and disrupted neuron-glia communication. Our study provides a comprehensive single-cell atlas of the hippocampal neuroimmune landscape in PTSD and highlights dysfunctional glial-neuronal interactions as a central mechanism underlying disease pathogenesis.
Authors
- Brent A. Wilkerson (ORCID: https://orcid.org/0000-0002-3532-3075)
- Z. Wang
- Amanda C. LaRue (ORCID: https://orcid.org/0000-0003-4572-1496)
- Steven L. Carroll (ORCID: https://orcid.org/0000-0001-6714-4373)
- Eric D. Hamlett (ORCID: https://orcid.org/0000-0002-2900-7949)
- Pengfei Li (ORCID: https://orcid.org/0000-0001-6436-4573)
- Hongkuan Fan
- Meng Liu
- Roger Shi
- Yan Wu
- Liu Liu
Institutions
- Medical University of South Carolina (US)
- High Magnetic Field Laboratory (CN)
- Ralph H. Johnson VA Medical Center (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1697171
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.00