Evaluating the Acute Effects of the Cannabinoid Dronabinol and the Opioid Hydromorphone Alone and in Combination: A Double-blind, Randomized, Placebo-controlled Trial in Knee Osteoarthritis
Opioid and cannabinoid medications failed to produce robust analgesia in experimentally induced pain among patients with knee osteoarthritis. In contrast to preclinical studies, there was no evidence of synergistic analgesic effects by combining hydromorphone and dronabinol.
Authors
- Traci J. Speed (ORCID: https://orcid.org/0000-0001-6102-2682)
- Katrina R. Hamilton (ORCID: https://orcid.org/0000-0002-1363-1616)
- Cecilia L. Bergeria (ORCID: https://orcid.org/0000-0002-8183-1273)
- Andrew S. Huhn (ORCID: https://orcid.org/0000-0002-8073-7701)
- Chung Jung Mun (ORCID: https://orcid.org/0000-0002-2439-8100)
- C. Macfie Campbell
- Kelly E. Dunn
- Ryan Vandrey
- Eliot Sadik
Institutions
- University of Maryland, Baltimore (US)
- Johns Hopkins University (US)
- Johns Hopkins Medicine (US)
- Behavioral Pharma (United States) (US)
- Ohio University (US)
- University of Baltimore (US)
Publication Details
- Journal
- Anesthesiology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1097/aln.0000000000005925
- Primary Topic
- Cannabis and Cannabinoid Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00