HPV-driven transcriptome and splicing rewiring under SRPK1 inhibition in cervical cancer
SRPK1 inhibition may remodel the cervical cancer transcriptome in an HPV-linked manner, with SiHa cells exhibiting changes consistent with suppression of oncogenic signaling, whereas C33A cells adapt through translational and metabolic reprogramming.
Authors
- Rahaba Marima (ORCID: https://orcid.org/0000-0001-5050-7350)
- Afra Basera (ORCID: https://orcid.org/0000-0001-8120-4555)
- Mohammed Alaouna (ORCID: https://orcid.org/0000-0002-1382-2332)
- Janie Duvenhage (ORCID: https://orcid.org/0000-0002-5770-7213)
- Zodwa Dlamini (ORCID: https://orcid.org/0000-0002-8012-3646)
- David O. Bates
Institutions
- South African Nuclear Energy Corporation (South Africa) (ZA)
- Steve Biko Hospital (ZA)
- Climate Resilience Infrastructure Development Facility (ZA)
- Precision Research (United States) (US)
- Sunny BioDiscovery (United States) (US)
- University of Glasgow (GB)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.3389/fonc.2025.1712170
- Primary Topic
- RNA Research and Splicing
- Type
- article
- Field-Weighted Citation Impact
- 0.00