STING activation by teniposide: a potential direct mechanism beyond cGAS stimulation
These findings suggest that Teniposide activates STING through a previously unrecognized, cGAS-independent mechanism, while retaining potential for canonical cGAS-STING stimulation. Our combined computational and experimental evidence supports repurposing Teniposide as a STING agonist, highlighting new therapeutic possibilities for innate immune stimulation.
Authors
- Sergio Rius‐Rocabert (ORCID: https://orcid.org/0000-0002-2193-5193)
- Estanislao Nistal‐Villán (ORCID: https://orcid.org/0000-0003-2458-8833)
- Javier Arranz-Herrero (ORCID: https://orcid.org/0000-0002-4107-2460)
- Rubén M. Buey (ORCID: https://orcid.org/0000-0003-1263-0221)
- Laura Márquez-Cantudo (ORCID: https://orcid.org/0000-0002-1618-1366)
- Lisa Miorin (ORCID: https://orcid.org/0000-0003-0989-3178)
- Claire Coderch (ORCID: https://orcid.org/0000-0001-7229-8289)
- Adrián Velázquez‐Campoy (ORCID: https://orcid.org/0000-0001-5702-4538)
- Vicent Tur-Planells (ORCID: https://orcid.org/0009-0001-8502-6183)
- Adolfo García-Sastre
- Beatriz de Pascual-Teresa
Institutions
- Universidad San Pablo CEU (ES)
- Universidad de Salamanca (ES)
- Universidad de Zaragoza (ES)
- Instituto de Salud Carlos III (ES)
- Tisch Hospital (US)
- Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (ES)
- Instituto de Investigación Sanitaria Aragón (ES)
- Icahn School of Medicine at Mount Sinai (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1677836
- Primary Topic
- interferon and immune responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Banco Santander
- Comunidad de Madrid
- Ministerio de Ciencia e Innovación
- Instituto de Salud Carlos III
- National Institute of Allergy and Infectious Diseases