Vagus Nerve Stimulation Paired With Upper Extremity Rehabilitation for Chronic Stroke: Real-World Implementation and Outcomes

VNS paired with rehabilitation therapy in patients with chronic ischemic stroke resulted in meaningful functional improvements aligned with individual patient goals in a real-world practice setting. Our results support findings from the pivotal VNS-REHAB (Vagus nerve stimulation paired with rehabilitation for upper limb motor function after ischaemic stroke): a randomised, blinded, pivotal, device trial and provide evidence for the feasibility of paired VNS program implementation in clinical practice.