Ketosis suppression and ageing (KetoSAge): the effect of suppressing ketosis on SHBG and sex hormone profiles in healthy premenopausal women, and its implications for cancer risk and therapy
SHBG is a sensitive biomarker of metabolic-endocrine status, with broader implications for cancer, and reproductive function. Chronic hypoketonaemia negatively affects SHBG production and hormonal balance. The implications of sex-hormone regulation for cancer prevention and therapy are discussed.
Authors
- Lucy Petagine (ORCID: https://orcid.org/0000-0003-2457-4001)
- Thomas N. Seyfried (ORCID: https://orcid.org/0000-0003-1491-3989)
- Derek C. Lee
- Tomás Duraj (ORCID: https://orcid.org/0000-0002-7778-0194)
- Isabella D. Cooper (ORCID: https://orcid.org/0000-0001-7374-4340)
- Yvoni Kyriakidou (ORCID: https://orcid.org/0000-0002-8883-2228)
- Naja Cooper
- Adrian Soto-Mota
Institutions
- Boston College (US)
- Queen Mary University of London (GB)
- Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán (MX)
- University of Westminster (GB)
- Tecnológico de Monterrey (MX)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2026-01-02
- DOI
- https://doi.org/10.3389/fnut.2025.1731915
- Primary Topic
- Diet and metabolism studies
- Type
- article
- Field-Weighted Citation Impact
- 0.00