An integrative model of pro- and anti-inflammatory signaling pathways in macrophage differentiation: the role of NF-κB and CREB
The complex network approach presented here integrates diverse cytokine and antigenic signaling leading to macrophage responses. It supports a mechanism for the IFN-<i>γ</i> mediated inhibition of CREB in the balance between pro-inflammatory and anti-inflammatory signals.
Authors
- Leonor Cariola Huerta
- David Martínez-Méndez (ORCID: https://orcid.org/0000-0002-4812-6118)
- Luis Jiménez-Álvarez (ORCID: https://orcid.org/0000-0002-5326-2720)
- Carlos Villarreal
- Lilian S. Castelán-Pacheco
- Joaquín Zúñiga
- Alfredo Cruz-Lagunas
- Ilean Z. Aguilar-Elguea
Institutions
- Instituto Nacional de Enfermedades Respiratorias (MX)
- Universidad Nacional Autónoma de México (MX)
- Tecnológico de Monterrey (MX)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1639005
- Primary Topic
- Immune cells in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00