Identification of key genes related to metabolic cell death in hepatic ischemia-reperfusion injury from transcriptome data and mechanism research using single-cell data

In HIRI pathogenesis research, ATF3, TNFAIP3, IL1B and KDM6B were validated as core regulators of metabolic cell death, offering critical targets for mechanistic investigation.

Authors

Institutions

Publication Details

Journal
Frontiers in Immunology
Published
2026-01-02
DOI
https://doi.org/10.3389/fimmu.2025.1695979
Primary Topic
Ferroptosis and cancer prognosis
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Identification of key genes related to metabolic cell death in hepatic ischemia-reperfusion injury from transcriptome data and mechanism research using single-cell data

Jiebo Wang, Hongli Yu, Yingli Cao, Xianfeng Weng et al.
Frontiers in Immunology
Ferroptosis and cancer prognosis
article

Identification of key genes related to metabolic cell death in hepatic ischemia-reperfusion injury from transcriptome data and mechanism research using single-cell data

Jiebo Wang, Hongli Yu, Yingli Cao, Xianfeng Weng, W. Xu
article en

Abstract

In HIRI pathogenesis research, ATF3, TNFAIP3, IL1B and KDM6B were validated as core regulators of metabolic cell death, offering critical targets for mechanistic investigation.

Frontiers in ImmunologyVol. 16
Fujian Medical University (CN), Peking University (CN), Tianjin First Center Hospital (CN), Peking University Third Hospital (CN), Union Hospital (CN), Tianjin Medical University (CN)
Good health and well-being
Openalex Percentile: Top 99%
Ferroptosis and cancer prognosis
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.