Molecular profiling of chemotherapy-resistant breast cancer reveals DNA methylation remodeling associated with the acquisition of paclitaxel resistance
Chemoresistance in BC involves extensive genomic and epigenetic remodeling. Although DAC can modulate methylation and tumor phenotype, rational drug combinations will be required to overcome resistance.
Authors
- Vojtěch Bystrý (ORCID: https://orcid.org/0000-0001-5278-0801)
- Andrej Ficek (ORCID: https://orcid.org/0000-0001-7526-2361)
- Jana Plavá (ORCID: https://orcid.org/0000-0002-9356-6219)
- Verona Buociková (ORCID: https://orcid.org/0000-0002-2466-9126)
- Lucia Rojikova
- Monika Buríková (ORCID: https://orcid.org/0000-0002-4697-6389)
- Mgr. Božena Smolková
- Lucia Kučerová (ORCID: https://orcid.org/0000-0002-6407-6659)
- Lenka Trnkova (ORCID: https://orcid.org/0000-0003-3510-9914)
- Andrea Čumová (ORCID: https://orcid.org/0000-0003-2485-3895)
- Florence Busato (ORCID: https://orcid.org/0000-0002-1459-7712)
- Andrea Šoltýsová (ORCID: https://orcid.org/0000-0002-1402-3583)
- Svetlana Miklikova (ORCID: https://orcid.org/0000-0003-0692-1858)
- Kristína Jakič (ORCID: https://orcid.org/0000-0002-8251-5328)
- Miroslava Matúšková (ORCID: https://orcid.org/0000-0002-0747-9275)
- Boris Tichy
- Jorg Tost
- Thomas Fleischer
- Marina Cihova
- Yimin Shen
- Geir Frode Øy
- Gunhild Mari Mælandsmo
- Eva Sedlackova
Institutions
- Oslo University Hospital (NO)
- Central European Institute of Technology (CZ)
- Institute of Chemistry of the Slovak Academy of Sciences (SK)
- Slovak Academy of Sciences (SK)
- Commissariat à l'Énergie Atomique et aux Énergies Alternatives (FR)
- Université Paris-Saclay (FR)
- Norwegian Cancer Society (NO)
- Fondation Jean Dausset-CEPH (FR)
- Centre National de Recherche en Génomique Humaine (FR)
- Central European Institute of Technology – Masaryk University (CZ)
- Direction de la Recherche Fondamentale (FR)
- Biomedical Research Center of the Slovak Academy of Sciences (SK)
- CEA Paris-Saclay (FR)
- Comenius University Bratislava (SK)
Publication Details
- Journal
- Drug Resistance Updates
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1016/j.drup.2026.101350
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00