White matter hyperintensity burden in young patent foramen ovale patients and its correlation with migraine
Young PFO patients exhibit an increased WMH burden, and PFO diameter serves as an independent risk factor for WMH grade. These findings suggest that PFO may contribute to the development of WMH in young individuals, potentially through mechanisms involving paradoxical embolism and chronic cerebral hypoperfusion. In young patients with PFO and migraine, monitoring WMH burden via neuroimaging may provide insights for future personalized management strategies.
Authors
- Bo Li (ORCID: https://orcid.org/0000-0002-7294-6888)
- Qun Shang (ORCID: https://orcid.org/0000-0001-7237-339X)
- Wei Zhao (ORCID: https://orcid.org/0000-0001-7138-0993)
- Y. Li
- Yangyingqiu Liu
- Jianbin Xin (ORCID: https://orcid.org/0000-0002-1024-4135)
- Ye Meng
- Xinying Shi
- Jiaqi Li
- Wenjing Zheng
- Jinfeng Cao
- Xin Luo
Institutions
- Binzhou Medical University (CN)
- Shandong University of Aeronautics (CN)
- The People's Hospital Tongling (CN)
- Central Hospital of Zibo (CN)
- Siemens Healthcare (United States) (US)
Publication Details
- Journal
- Frontiers in Neurology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.3389/fneur.2025.1737566
- Primary Topic
- Cardiovascular and Diving-Related Complications
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shandong Province