TrkB Overexpression via Gene Therapy: Enhanced Optic Nerve Uptake With Associated Increases in Mitochondria and Axoplasmic Transport
This study provides early indications that improving TrkB expression in the eye may increase anterograde transport of motor proteins, which in turn could improve mitochondrial transport within the optic nerve.
Authors
- Keith R. Martin (ORCID: https://orcid.org/0000-0002-9347-3661)
- Andrew Osborne (ORCID: https://orcid.org/0000-0002-5649-2337)
- Sadat Yazdouni (ORCID: https://orcid.org/0000-0003-2477-6981)
Institutions
- Imperial College Healthcare NHS Trust (GB)
- The University of Melbourne (AU)
- Norwich University (US)
- Norwich Research Park (GB)
- The Royal Victorian Eye & Ear Hospital (AU)
- Cambridge School (PT)
- Bridge University (SS)
- Centre for Eye Research Australia (AU)
- Addenbrooke's Hospital (GB)
Publication Details
- Journal
- Cureus
- Published
- 2026-01-02
- DOI
- https://doi.org/10.7759/cureus.100594
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 0.00