Urinary Antimicrobial Peptides and Cytokines as Biomarkers for Recurrent Urinary Tract Infection in Children and Adolescents
Girls and adolescent females with rUTI exhibit a distinct urinary immune profile characterized by dysregulated antimicrobial peptides and elevated proinflammatory cytokines. A predictive model integrating these biomarkers with clinical features accurately classified rUTI status, supporting their potential utility as diagnostic tools for pediatric UTI.
Authors
- Christina Barbara Ching (ORCID: https://orcid.org/0000-0002-3396-4215)
- Laura Schwartz (ORCID: https://orcid.org/0000-0003-3550-7912)
- Steve Rust (ORCID: https://orcid.org/0000-0001-8492-7337)
- Hancong Tang (ORCID: https://orcid.org/0000-0003-3986-0617)
- Natalie Holdsworth
- Kristin Salamon
- John David Spencer
- Guillermo Yepes
Institutions
- Nationwide Children's Hospital (US)
- Ohio University (US)
- The Ohio State University (US)
Publication Details
- Journal
- medRxiv
- Published
- 2026-01-02
- DOI
- https://doi.org/10.64898/2025.12.29.25343150
- Primary Topic
- Urinary Tract Infections Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Nationwide Children's Hospital
- National Institutes of Health
- National Institute of Diabetes and Digestive and Kidney Diseases