MiR-10a-5p suppresses hepatocellular carcinoma progression and microvascular invasion by targeting TFR1-STAT3-CD24 signaling axis

Our findings reveal miR-10a-5p as a key regulator of HCC progression and MVI, operating through a novel pathway involving TFR1, STAT3, and CD24. This study provides new insights into the molecular mechanisms of CT features and highlights potential therapeutic targets for HCC treatment.

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Publication Details

Journal
Frontiers in Oncology
Published
2026-01-02
DOI
https://doi.org/10.3389/fonc.2025.1694441
Primary Topic
MicroRNA in disease regulation
Type
article
Field-Weighted Citation Impact
0.00
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article

MiR-10a-5p suppresses hepatocellular carcinoma progression and microvascular invasion by targeting TFR1-STAT3-CD24 signaling axis

Xiaoyue Nong, Rulin Xu, Yupeng Zhang, Wei Zhang et al.
Frontiers in Oncology
MicroRNA in disease regulation
article

MiR-10a-5p suppresses hepatocellular carcinoma progression and microvascular invasion by targeting TFR1-STAT3-CD24 signaling axis

Xiaoyue Nong, Rulin Xu, Yupeng Zhang, Wei Zhang, Yingying Chen, Tao Bai, Di Lai, Ziyi Wang
article en

Abstract

Our findings reveal miR-10a-5p as a key regulator of HCC progression and MVI, operating through a novel pathway involving TFR1, STAT3, and CD24. This study provides new insights into the molecular mechanisms of CT features and highlights potential therapeutic targets for HCC treatment.

Frontiers in OncologyVol. 15
Canon (Japan) (JP), Guangxi Medical University (CN), Liuzhou General Hospital (CN), Fourth Affiliated Hospital of Guangxi Medical University (CN), Tumor Hospital of Guangxi Medical University (CN)
Good health and well-being
Openalex Percentile: Top 99%
MicroRNA in disease regulation
DOIOpen Access PDFOpenAlex
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