Using generative artificial intelligence to standardize unstructured antigen profiles for the alloantibody exchange

Commercial LLMs can standardize unstructured antigen profiles with high accuracy when paired with schema-guided decoding and error-aware retries. The high accuracy shown by the LLMs suggests they would offer significant scalability while reducing manual curation for a national transfusion history sharing service like the alloantibody exchange. They represent a foundational technology for enabling such a service.

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Publication Details

Journal
Transfusion
Published
2026-01-02
DOI
https://doi.org/10.1111/trf.70061
Primary Topic
Blood groups and transfusion
Type
article
Field-Weighted Citation Impact
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article

Using generative artificial intelligence to standardize unstructured antigen profiles for the alloantibody exchange

Eileen V. Alvarez, Kristi Lazar Cantrell, D. Wright, Ronald George Hauser et al.
Transfusion
Blood groups and transfusion
article

Using generative artificial intelligence to standardize unstructured antigen profiles for the alloantibody exchange

Eileen V. Alvarez, Kristi Lazar Cantrell, D. Wright, Ronald George Hauser, Jack M. Sullivan, Kent McCann
article en

Abstract

Commercial LLMs can standardize unstructured antigen profiles with high accuracy when paired with schema-guided decoding and error-aware retries. The high accuracy shown by the LLMs suggests they would offer significant scalability while reducing manual curation for a national transfusion history sharing service like the alloantibody exchange. They represent a foundational technology for enabling such a service.

TransfusionVol. 66(3)
University of Michigan (US), Yale University (US), VA Connecticut Healthcare System (US), Institute for Transfusion Medicine (US)
Openalex Percentile: Top 99%
Blood groups and transfusion
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