Peripheral alpha-2 antagonist vatinoxan improves dexmedetomidine-induced perivascular cerebrospinal fluid flow without affecting electroencephalogram activity in female rats
Antagonism of peripheral α<sub>2</sub>-adrenergic receptors with vatinoxan during dexmedetomidine sedation enhances perivascular CSF influx, irrespective of slow-wave activity.
Authors
- Terhi J. Lohela (ORCID: https://orcid.org/0000-0002-6596-1780)
- Niklas Daniel Åke Persson (ORCID: https://orcid.org/0000-0003-3755-4579)
- Sonja C. Jalonen
- Hanna Antila
- Martta Peltoniemi
- Tuomas O. Lilius
Institutions
- University of Helsinki (FI)
Publication Details
- Journal
- Neuropharmacology
- Published
- 2026-01-02
- DOI
- https://doi.org/10.1016/j.neuropharm.2026.110828
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 0.00